The Sculptor Group, which appears to be our nearest neighbor group, lies some 8 million light-years away. Its brightest members are NGC 253 and NGC 55. Easily visible also are NGC 45, NGC 247, NGC 300 and NGC 7793. All these are spirals with the exception of NGC 55, which is an irregular galaxy.
The Ursa Major Group, believed to be a bit farther than the Sculptor Group, is dominated by the bright and peculiar spirals known as Bode's Galaxies (M81 and M82), which are easily seen in binoculars. The Ursa Major Group is a large and scattered group with ill-defined limits. NGC 2403 and IC 342 (both in Camelopardalis) are considered the principal galaxies of amorphous thickenings or clumps in the Ursa Major Group.
The M101 Group, situated more or less around the far tip of the Big Dipper's handle, lies 15-20 million light-years away. M101, M63 and M51 are its principal denizens. Ursa Major's M101 is "one of the largest galaxies in the heavens in terms of surface area" (Crossen). M63 and M51 (the Whirlpool) are found in Canes Venatici. All three are large spirals, easily seen. The M101 Group is sometimes called the Canes Venatici Group.
The Centaurus Group lies some 13 million light-years away in the southern skies. The northern limit of this large group is near Spica, where one of its larger spirals (M83) was noticed by Pierre Mechain, while collaborating with Messier in 1781. Other prominent group members (arranged more or less in a long chain), notably NGC 5068, NGC 5253, NGC 5102, NGC 5128, and NGC 4945, are best enjoyed by southern observers.
The Leo Group, lying some 25 million light-years away, consists of two major clumps known (more or less unofficially) as the East and West subgroups. M65 and M66 are the principal members of the east subgroup; whereas M95, M96, and M105 dominate the west subgroup. All of these, as well as many smaller galaxies, are easily seen in giant binoculars and small, rich-field telescopes on clear dark nights.
The Coma-Virgo Supercluster, also known as The Realm of The Galaxies, lies some 50 million light-years away and is dominated by the enormous M87, a most mysterious, bright and unusual elliptical galaxy. Smooth and featureless, M87 was recognized as a very strong radio source only recently, in 1954. William Herschel had noted the unusual number of "nebula" here in 1785 but he was unaware of the true nature of this supercluster. Likewise Charles Messier, always searching for comets, did not realize the supercluster's importance as he duly recorded (beginning in February, 1771) some of its more obvious members -- M58, M88, M90, M98, M99, M100 (spirals) and M49, M59, M60, M61, M84, M85, M86, M87, M89 (elipticals).
In addition to the foregoing, there are many other clusters and groups of galaxies out there, most of which are much more distant and/or very faint. No doubt many more have yet to be discovered. Known to exist are other groups in Fornax, Leo (the so-called deep-sky "Leo II Group"), Hercules, and Corona Borealis.
Much of this material was extracted from a chapter -- "Galaxies and Galaxy Groups for Binoculars" -- in Crossen's superb book and represents but a smattering of the wealth of information available on the subject of galactic mapping. This book, incidentally, is recommended in the subpage "Starting Out" found above.